Chi Longevity: Singapore's Evidence-Based Longevity Clinic

Chi Longevity operates two licensed clinics in Singapore: the original site at Camden Medical Centre, and a second location at the Four Seasons Hotel Singapore that opened in January 2025. A third facility, SPARKD by Chi Longevity, is the team's proprietary cognitive-physical training facility, which moved into the Four Seasons in April 2026.

Patients are seen by a multidisciplinary team of internists, dietitians, psychologists, brain-health trainers, and health coaches, all working under a shared protocol so that each client's biological, clinical, cognitive, and lifestyle data is reviewed together.

Chi Longevity's philosophy starts from a refusal: it does not deal in unvalidated interventions. Asked about the field's enthusiasm for novel therapies, Prof. Maier has been blunt that there is no conclusive evidence for stem cell therapies, drips, or juices. The clinic's model is that supplements and treatments enter clinical practice only when trial data shows a meaningful benefit that outweighs the side effects.

The clinic focuses on healthspan rather than radical lifespan extension: the years a person lives with capability, independence, and clarity.

Chi Longevity's clinical framework is named The Maier Method, structured in three steps. The clinic's own framing is that the data itself is necessary but not sufficient. What matters most is how data interconnects, and how that interconnection is clinically interpreted.

Beyond comprehensive blood and urine panels and NAD+ levels, the clinic uses epigenetic and inflammation-based biological age clocks alongside arterial stiffness, stress ECG, VO₂ max, and cardiopulmonary exercise testing. Cognition is assessed across attention, memory, processing speed, and executive function, with dual-task testing that integrates cognitive and physical load.

Continuous glucose monitoring, gut microbiome analysis, genetic and epigenetic panels, wearable-based sleep and activity tracking, and a structured battery of physical-function measures round out the workup. All this data feeds SPARKD, the clinic's proprietary cognitive-physical training facility, where strength, balance, and motor-coordination work is paired with simultaneous cognitive load to target the specific weaknesses discovered in the tests.

That commitment to scientific rigor extends to the clinicians themselves. Dr. Oh describes data ingestion as one of the biggest challenges facing longevity today. He works with open-source biological age clocks and uses a medical large language model with access to published studies for evidence-based clinical decision support. Longitudinal risk calculators, such as a 10-year cardiovascular risk score, are recomputed as new lab and lifestyle data come in, so that intervention plans evolve with the client's biology rather than being re-issued from scratch each visit.

Prof. Maier has authored more than 500 peer-reviewed publications spanning translational aging biology, geropsychiatry, cellular senescence, and digital biomarkers. That work is now extending into personalisation, with active research at the NUS Academy for Healthy Longevity. In December 2025, she was named Longevity Ambassador at the International Institute of Longevity and Roundtable of Longevity Clinics global event, in recognition of her work to establish standards for the field.

Asked where the field will be in five to ten years, Maier has been concrete. In the near term she expects rapid progress on combining validated interventions; over a slightly longer horizon, she anticipates a shift toward continuous, biosensor-driven delivery, with patches that dose directly based on real-time measurements.

Where Chi Longevity is positioning itself in that future is not as a maximalist clinic chasing every new compound, but as a standards-setter. Prof. Maier is the founding President of the Healthy Longevity Medicine Society, established in 2022 to build a clinically credible framework for the field and publish recommendations and guidelines. She also chairs a working group developing clinical practice guidelines for longevity clinics, and advises the WHO, the UN, and the Hevolution Foundation.